Protective Effect of Vitamin C against Carbofuran-Induced Testicular Toxicity in Albino Mice
نویسنده
چکیده
The effect of the carbamate insecticide "carbofuran" on testes of male albino mice and the possible protective role of vitamin C against the insecticide toxicity was assessed. Treating mice with carbofuran for 8 weeks induced a significant decrease in the diameters and germinal epithelial heights of the seminiferous tubules. The histological evidence showed inhibition of spermatogenesis. There was also a decline in sperm count. Histochemical results revealed that animals given carbofuran had decreased contents of carbohydrates and total proteins in the testicular tissue. Treating mice with carbofuran and vitamin C showed an improvement in the testicular damage. The seminiferous tubules appeared normal and the different stages of spermatogenic cells showed an advanced degree of activation. [Wael M. Al-Amoudi. Protective Effect of Vitamin C against Carbofuran-Induced Testicular Toxicity in Albino Mice] Journal of American Science 2012; 8(1):335-341]. (ISSN: 1545-1003). http://www.americanscience.org.
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